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. Author manuscript; available in PMC: 2013 Aug 13.
Published in final edited form as: J Mech Behav Biomed Mater. 2011 Mar 16;4(6):829–840. doi: 10.1016/j.jmbbm.2011.03.009

Figure 2.

Figure 2

The ovine critical sized defect model (implemented in the femur for this study) provides multiple healing scenarios using a common surgical technique, enabling study of healing in the original critical sized defect (A), the newly created defect surrounded by periosteum (B), healing of a defect packed with morcellized autograft (C), and healing of a massive cortical autograft denuded of periosteum (D). This paper integrates and reviews these approaches to understanding de novo bone generation in defects (A,B), as well as bone remodeling and adaptation (C-D) under different conditions in a common surgical model. Figure adapted after (Knothe Tate et al., 2010A).