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Confocal micrographs showing early bone formation (green) in empty defects surrounded by periosteum (A) and defects packed with morcellized cancellous autograft (B). In the presence of autograft, new bone formation predominates between the outer edge of the autograft and the inner surface of the periosteum. In the absence of autograft, a rapid proliferative woven bone response is observed to fill the defect within the first weeks after surgery.
