Figure 3.

CEST experimental data from a hen egg white phantom (a). In (b), the inverted Z-spectrum is transformed into the time-domain and fit using three Lorentizian line shapes (the fitted line shapes are also displayed in the frequency domain in (c)). The component corresponding to the water peak (red line in (c)) is subtracted from the experimental data in the time domain and then the residual signal (d) is transformed back in the frequency domain. The filtered Z-spectrum (e) shows that the water component is largely removed thus leaving the residual signal to be analyzed with minimal interference.