Skip to main content
. Author manuscript; available in PMC: 2013 Aug 13.
Published in final edited form as: J Nutr. 2012 Jan 5;142(2):213–220. doi: 10.3945/jn.111.147132

TABLE 2.

Plasma AUC for glucose and satiety hormones of obese rats treated with OFS, MET, both, or neither for 7 wk1

C OFS MET OFS+MET Diet Drug Diet × drug
P value
Glucose, mmol/L × 90 min 891 ± 49.2 707 ± 40.3 759 ± 35.5 637 ± 30.4 0.002 0.025 0.45
Insulin, nmol/L × 90 min 26.3 ± 1.94 30.3 ± 3.58 10.5 ± 2.29 15.8 ± 1.60 0.07 0.001 0.78
Amylin, nmol/L × 90 min 1.06 ± 0.17 1.30 ± 0.16 0.59 ± 0.14 0.62 ± 0.11 0.37 0.001 0.46
Leptin, nmol/L × 90 min 107 ± 9.22c 70.5 ± 8.74b 34.1 ± 6.34a 37.4 ± 1.06a 0.047 0.001 0.019
Ghrelin, nmol/L × 90 min 5.16 ± 0.47 2.97 ± 0.15 3.41 ± 0.59 3.06 ± 0.21 0.013 0.15 0.09
PYY, nmol/L × 90 min 0.79 ± 0.05 1.15 ± 0.13 0.70 ± 0.05 0.89 ± 0.07 0.006 0.06 0.34
GIP, nmol/L × 90 min 2.30 ± 0.29c 1.20 ± 0.09b 1.04 ± 0.16b 0.57 ± 0.04a 0.001 0.001 0.044
GLP-1, nmol/L × 90 min 0.41 ± 0.09 0.47 ± 0.04 0.41 ± 0.02 0.49 ± 0.04 0.012 0.024 0.16
1

Values are mean ± SEM, n = 8–10. Labeled means in a row without a common letter differ, P < 0.05. C, control; GIP, glucose-dependent insulinotropic polypeptide; GLP-1, glucagon-like peptide 1; MET, metformin; OFS, oligofructose; PYY, peptide tyrosine tyrosine.