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Kinetics of CD4 T-cell responses in TNFR-deficient mice during a chronic LCMV infection. Groups of mice were infected with LCMV-clone 13, and on the indicated days postinfection virus-specific CD4 T-cell responses were quantitated by intracellular staining for IFN-γ following in vitro stimulation with the MHC-II-restricted epitope peptide GP61-80. The data are the means of at least three mice per group at each time point ± the standard deviation.
