FIG. 2.

MHC-I-restricted cytotoxicity in the spleens of LCMV-clone 13-infected mice. (A) Eight days after infection with LCMV-Arm, the LCMV-specific MHC-I-restricted cytotoxic activity in the spleens of +/+ mice was quantitated by a ⁵¹Cr-release assay using syngeneic LCMV-infected and uninfected MC57G cells as target cells. (B) Groups of +/+ and TNFR-deficient mice were infected with LCMV-clone 13, and cytotoxic activity in the spleen was quantitated 8 days later as described for panel A. Data are the mean of three to six mice per group, ± the standard deviation.