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Kinetics of IFN-γ-producing CD8 T cells in TNFR-deficient mice during a chronic LCMV infection. On the indicated days after infection with LCMV-clone 13, splenocytes were stimulated with the indicated CTL epitope peptide (NP396, GP33, and GP276) and the number of IFN-γ-producing CD8 T cells was determined by intracellular staining followed by flow cytometry. The data are the means of at least three mice per group at each time point ± the standard deviation.
