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Functional unresponsiveness of CD8 T cells in persistently infected TNFR-deficient mice. At 195 days after infection with LCMV-clone 13, splenocytes were stimulated with the indicated LCMV CTL epitope peptide and the number of IFN-γ-producing CD8 T cells was determined by intracellular staining. The dot plots are gated on total splenocytes, and the numbers represent percentages of IFN-γ-producing CD8 T cells per total splenocytes.
