Table 3. Baseline characteristics stratified by caseness of depression: Biomarkers.

Dependent variables	No Depression (ND) PHQ-9<10 91.6% (n = 4580)	Depression PHQ-9≥10 7.1% (n = 357)	Linear Regression models,β-estimate (95% CI), p adj.for age and sex	Logistic Regression models, OR (95% CI), p adj. for age and sex
Biomarkers *
*CRP≥3 mg/l, % (n)	23.4 (846)	28.8 (69)		1.35 (1.00, 1.80), 0.047
*IL-18, pg/ml, median (IQR)	227.0 (180.6, 290.4)	219.9 (172.0, 290.9)	0.0081 (−0.039, 0.055), 0.73
*IL-1-Ra, pg/ml *, median (IQR)	316 (235.5, 417.3)	336.2 (247.6, 490.7)	0.084 (0.027, 0.14), 0.0042
*Albumin, g/l *, mean ±1.96 sd	43.2 (37.0, 49.4)	42.5 (36.2, 48.8)	−0.74 (−1.14, −0.35), 0.0002
Fibrinogen, mg/dl, median (IQR)	345.0 (303.0, 398.0)	350.0 (298.0, 416.0)	0.019 (−0.0030, 0.042), 0.090
NTproBNP, pg/ml, median (IQR)	61.5 (28.3, 123.7)	64.8 (29.4, 113.4)	0.0041 (−0.12, 0.13), 0.95
Endothelial function
Systolic blood pressure before measurement of Endothelialfunction; mean ±1.96 sd	133.8 (99.3, 168.9)	130.9 (98.3, 163.4)	−0.79 (−2.50, 0.92), 0.37
Baseline brachial artery diameter,mm, mean ±1.96 sd	4.33 (2.71, 5.96)	4.16 (2.61, 5.71)	0.00044 (−0.061, 0.062), 0.99
Flow-mediated dilatation, % *,median (IQR)	7.13(4.41, 10.67)	7.83 (5.14, 11.44)	0.37 (−0.16, 0.92), 0.17

Adjusted regression analysis for the independent variable depression. An odds ratio adjusted for age and sex with corresponding 95%-confidence interval and p-value is given for CRP. For the other dependent variables linear regressions have been done. In this case, the regression coefficient with corresponding 95%-confidence intervals and p-values were given.

Data presented are median (25^th/75^th) percentile, mean ±1.96 sd, absolute and relative frequencies of subjects.

^*Subjects with a self reported influenza infection, common cold or other inflammatory diseases during the last week before examination or CRP≥10 mg/dl were excluded.