Table 3. Baseline characteristics stratified by caseness of depression: Biomarkers.
Dependent variables | No Depression (ND) PHQ-9<10 91.6% (n = 4580) | Depression PHQ-9≥10 7.1% (n = 357) | Linear Regression models,β-estimate (95% CI), p adj.for age and sex | Logistic Regression models, OR (95% CI), p adj. for age and sex |
Biomarkers * | ||||
*CRP≥3 mg/l, % (n) | 23.4 (846) | 28.8 (69) | 1.35 (1.00, 1.80), 0.047 | |
*IL-18, pg/ml, median (IQR) | 227.0 (180.6, 290.4) | 219.9 (172.0, 290.9) | 0.0081 (−0.039, 0.055), 0.73 | |
*IL-1-Ra, pg/ml *, median (IQR) | 316 (235.5, 417.3) | 336.2 (247.6, 490.7) | 0.084 (0.027, 0.14), 0.0042 | |
*Albumin, g/l *, mean ±1.96 sd | 43.2 (37.0, 49.4) | 42.5 (36.2, 48.8) | −0.74 (−1.14, −0.35), 0.0002 | |
Fibrinogen, mg/dl, median (IQR) | 345.0 (303.0, 398.0) | 350.0 (298.0, 416.0) | 0.019 (−0.0030, 0.042), 0.090 | |
NTproBNP, pg/ml, median (IQR) | 61.5 (28.3, 123.7) | 64.8 (29.4, 113.4) | 0.0041 (−0.12, 0.13), 0.95 | |
Endothelial function | ||||
Systolic blood pressure before measurement of Endothelialfunction; mean ±1.96 sd | 133.8 (99.3, 168.9) | 130.9 (98.3, 163.4) | −0.79 (−2.50, 0.92), 0.37 | |
Baseline brachial artery diameter,mm, mean ±1.96 sd | 4.33 (2.71, 5.96) | 4.16 (2.61, 5.71) | 0.00044 (−0.061, 0.062), 0.99 | |
Flow-mediated dilatation, % *,median (IQR) | 7.13(4.41, 10.67) | 7.83 (5.14, 11.44) | 0.37 (−0.16, 0.92), 0.17 |
Adjusted regression analysis for the independent variable depression. An odds ratio adjusted for age and sex with corresponding 95%-confidence interval and p-value is given for CRP. For the other dependent variables linear regressions have been done. In this case, the regression coefficient with corresponding 95%-confidence intervals and p-values were given.
Data presented are median (25th/75th) percentile, mean ±1.96 sd, absolute and relative frequencies of subjects.
Subjects with a self reported influenza infection, common cold or other inflammatory diseases during the last week before examination or CRP≥10 mg/dl were excluded.