Table 6. Multivariable adjusted associations of somatic versus cognitive symptom dimensions of depression.
| Dependent variables | Somatic symptom subscale (0–12) | Cognitive symptom subscale (0–15) | ||
| Logistic Regression models,OR (95% CI), p | Linear Regressionmodels, β-estimate(95% CI), p | Logistic Regressionmodels, OR (95% CI), p | Linear Regression models, β-estimate (95% CI), p | |
| CHD | 1.25 (1.14, 1.39), <0.0001 | 1.02 (0.92, 1.13), 0.68 | ||
| History of MI | 1.22 (1.09, 1.37), <0.001 | 0.99 (0.88, 1.13), 0.92 | ||
| Family history of MI# | 1.08 (1.02, 1.14), 0.0055 | 1.02 (0.96, 1.07), 0.51 | ||
| Diabetes | 0.97 (0.89, 1.06), 0.53 | 1.05 (0.96, 1.15), 0.29 | ||
| Hypertension | 1.01 (0.96, 1.06), 0.77 | 0.96 (0.91, 1.00), 0.064 | ||
| Dyslipidemia | 1.09 (1.04, 1.14), <0.001 | 0.99 (0.94, 1.04), 0.62 | ||
| Smoking (current) | 1.06 (1.01, 1.12), 0.019 | 1.00 (0.95, 1.06), 0.92 | ||
| Obesity (BMI ≥30) | 1.15 (1.09, 1.21), <0.0001 | 0.93 (0.88, 0.98), 0.0035 | ||
| Physical Activity score (continuous) | 36.05 (−38.25, 110.36), 0.34 | −27.94 (−103.68, 47.80), 0.47 | ||
| Medical history of depression | 1.22 (1.15, 1.30), <0.0001 | 1.39 (1.30, 1.47), <0.0001 | ||
| Type D personality | 1.13 (1.08, 1.19), <0.0001 | 1.51 (1.43, 1.60), <0.0001 | ||
| Biomarkers * | ||||
| CRP≥3 mg/dl (yes vs. no) | 1.02 (0.96, 1.09), 0.44 | 0.98 (0.92, 1.04), 0.45 | ||
| IL-18, pg/ml | 0.0061 (−0.0024, 0.015), 0.16 | −0.0056 (−0.014, 0.0030), 0.20 | ||
| IL-1-ra, pg/ml | 0.00067 (−0.0090, 0.010), 0.89 | 0.0021 (−0.0077, 0.012), 0.68 | ||
| Albumin, mg/l | −0.039 (−0.11, 0.032), 0.28 | −0.011 (−0.082, 0.061), 0.77 | ||
| Fibrinogen, mg/dl | 0.0013 (−0.0027, 0.0053), 0.53 | −0.0033 (−0.0074, 0.00079), 0.11 | ||
| NT-proBNP, pg/ml | 0.087 (−0.015, 0.032), 0.47 | −0.012 (−0.036, 0.012), 0.32 | ||
Adjusted for age, sex, dyslipidemia, current smoking, diabetes, hypertension, Body mass index, 5 kg/m2, Activity score (Q1–Q4), FH of MI and socioeconomic status (3–27). The predictors (somatic and cognitive subscale) were entered together in each regression analyses.
#
Exclusion of subjects with CHD attenuates the relationship of the somatic symptom scale with FH of MI only slightly OR 1.06 (1.00–1.12), p = 0.0361.
*
For analysis of CRP, IL-18, IL-1-ra, and Albumin subjects with a self reported influenza infection, common cold or other inflammatory diseases during the last week before examination or CRP≥10 mg/dl are excluded. All biomarkers except for Albumin and CRP were log transformed.