Table 2. Gene set enrichment analysis of representative gene sets identified as significantly enriched after CG-1521 treatment in SUM190PT cells.
| Downregulated functional classes | |||
|---|---|---|---|
|
GO ID |
Term |
No. of genes |
P value |
| GO:0000279 |
M phase |
23 |
2.26E -11 |
| GO:0006629 |
Lipid metabolic process |
28 |
4.80E-07 |
| GO:0019752 |
Carboxylic acid metabolic process |
17 |
6.21E-04 |
| GO:0016616 |
Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
8 |
1.52E-04 |
| Upregulated functional classes |
|
|
|
|
GO ID |
Term |
No. of genes |
P value |
| GO:0006629 |
Negative regulation of apoptosis |
18 |
1.95E-06 |
| GO:0016491 |
Response to unfold protein |
8 |
2.72E-05 |
| GO:0009055 | Response to stress | 40 | 7.58E-05 |
The full list of genes associated with these ontologies is provided in Table S3.