Table 2. The table represents visual estimations of mitochondrial appearance and localization within the cellular compartment of wild-type and mutant PXN.
| Mutant | Cellular Distribution | Appearance | Comments | |
|---|---|---|---|---|
| WT |
Cytoplasmic |
Perinuclear |
Dense; Network; Punctate |
punctate at moving front of cell; some in lamellipodia |
| P52L |
Cytoplasmic |
Extranuclear |
Discrete; Punctate |
cells are not easy to define |
| A127T |
Cytoplasmic |
Perinuclear |
Dense; Network; Punctate |
some adjacent normal cells also similar in appearance |
| P233L |
Cytoplasmic |
Extranuclear |
Dense; Network; Punctate |
in lamellipodia at moving front of cell; dense in moving direction |
| D399N |
Cytoplasmic |
Extranuclear |
Discrete; Punctate |
more pronounced at moving front (not in lamellipodia/filopodia) |
| P487L | Cytoplasmic | Extranuclear | Dense; Network; Punctate | in lamellipodia |
Four to eight individual cells were evaluated for each construct.