Table V.

Pathway analysis of downregulated genes in response to SeM treatment with cells harvested at 16 h post-irradiation.**

Symbol	Accession No.	Gene namea	Fold change	Pathway affected
10 cGy
No identifable pathways
20 cGy
MET	NM_000245	Met proto-oncogene	0.7	Focal adhesion
VCL	NM_003373	Vinculin	0.6	Focal adhesion
ITGAV	NM_002210	Integrin, alpha V	0.6	Focal adhesion, extracellular matrix receptor interaction
LAMB1	NM_002291	Laminin, beta 1	0.5	Focal adhesion, cell communication, extracellular matrix receptor interaction
TNC	NM_002160	Tenascin C	0.3	Focal adhesion, cell communication, extracellular matrix receptor interaction
THBS1	NM_003246	Thrombospondin 1	0.6	Focal adhesion, cell communication, extracellular matrix receptor interaction
COL4A2	NM_001846	Collagen, type IV, alpha 2	0.5	Focal adhesion, cell communication, extracellular matrix receptor interaction
COL4A1	NM_001845	Collagen, type IV, alpha 1	0.5	Focal adhesion, cell communication, extracellular matrix receptor interaction
FN1	NM_002026	Fibronectin 1	0.5	Focal adhesion, cell communication, extracellular matrix receptor interaction
LAMC1	NM_002293	Laminin, gamma 1	0.5	Focal adhesion, cell communication, extracellular matrix receptor interaction
DSC3	NM_001941	Desmocollin 3	0.6	Cell communication
DSG2	AAH99655	Desmoglein 2	0.6	Cell communication
CDH2	NM_001792	Cadherin 2, type 1, n-cadherin	0.6	Cell adhesion molecules
PTPRF	NM_002840	Protein tyrosine phosphatase, receptor type F	0.7	Cell adhesion molecules
NEO1	NM_002499	Neogenin homolog 1	0.7	Cell adhesion molecules
GLG1	NM_012201	Golgi apparatus protein 1	0.6	Cell adhesion molecules
VCAN	NM_004385	Chondroitin sulfate proteoglycan 2 (Versican)	0.4	Cell adhesion molecules
NCAM1	NM_000615	Neural cell adhesion molecule 1	0.6	Cell adhesion molecules
ITGAV	NM_002210	Integrin, alpha V	0.6	Cell adhesion molecules, small cell lung cancer
COL4A1	NM_001845	Collagen, type IV, alpha 1	0.5	Small cell lung cancer
FN1	NM_001846	Fibronectin 1	0.5	Small cell lung cancer
COL4A2	NM_002026	Collagen, type IV, alpha 2	0.5	Small cell lung cancer
LAMB1	NM_002291	Laminin, beta 1	0.5	Small cell lung cancer, Prion disease
LAMC1	NM_002293	Laminin, gamma 1	0.6	Small cell lung cancer, Prion disease
HSPA5	NM_005347	Heat shock 70 kDa protein 5	0.5	Prion disease
PTPRF	NM_002840	Protein tyrosine phosphatase, receptor type F	0.6	Adherens junction
INSR	NM_000208	Insulin receptor	0.6	Adherens junction
MET	NM_000245	Met proto-oncogene	0.7	Adherens junction
VCL	NM_003373	Vinculin	0.6	Adherens junction

^aWith SeM treatment of the 10 cGy irradiated cells, 15 genes were observed to be downregulated, but no significant effects on signaling pathways were observed. In contrast, with SeM treatment of the 20 cGy irradiated cells, genes are represented out of 123 unique transcripts observed to be downregulated and identified to affect the stated signaling pathways. SeM, L-selenomethionine.