Table 2. Distribution of age, smoking, drinking, and genotypes in chemical sensitive population (CSP) cases and controls.
| Controls (%) | Case 1 (%) | Pa,b | Case 2 (%) | Pa,b | Case 3 (%) | Pa,c | ||
|---|---|---|---|---|---|---|---|---|
| Low chemical sensitivity | Middle chemical sensitivity | High chemical sensitivity | ||||||
| n = 208 | n = 67 | n = 38 | n = 11 | |||||
| Age | <40 | 61 (29.3%) | 9 (13.4%) | 9 (23.7%) | 4 (36.4%) | |||
| 40–49 | 64 (30.8%) | 20 (29.9%) | 9 (23.7%) | 2 (18.2%) | ||||
| ≥50 | 83 (39.9%) | 38 (56.7%) | 0.02 | 20 (52.6%) | 0.34 | 5 (45.4%) | 0.74 | |
| Smoking | Non-smoker | 83 (39.9%) | 31 (46.3%) | 16 (42.1%) | 7 (63.6%) | |||
| Smoker | 125 (60.1%) | 36 (53.7%) | 0.36 | 22 (57.9%) | 0.80 | 4 (36.4%) | 0.11 | |
| Drinking | Non-drinker | 38 (18.3%) | 12 (17.9%) | 10 (26.3%) | 2 (18.2%) | |||
| Drinker | 170 (81.7%) | 55 (82.1%) | 0.95 | 28 (73.7%) | 0.25 | 9 (81.8%) | 0.68 | |
| NAT2 | ||||||||
| Genotype | Rapid | 90 (43.3%) | 36 (53.7%) | 20 (52.6%) | 7 (63.6%) | |||
| Inter + Slow | 118 (56.7%) | 31 (46.3%) | 0.14 | 18 (47.4%) | 0.29 | 4 (36.4%) | 0.16 | |
| GSTM1 | ||||||||
| Genotype | non-null | 121 (58.2%) | 37 (55.2%) | 18 (47.4%) | 4 (36.4%) | |||
| homozygous-null | 87 (41.8%) | 30 (44.8%) | 0.67 | 20 (52.6%) | 0.22 | 7 (63.6%) | 0.13 | |
| GSTT1 | ||||||||
| Genotype | non-null | 84 (40.4%) | 31 (46.3%) | 19 (50.0%) | 5 (45.5%) | |||
| homozygous-null | 124 (59.6%) | 36 (53.7%) | 0.40 | 19 (50.0%) | 0.27 | 6 (54.5%) | 0.49 | |
| GSTP1 | ||||||||
| Genotype | A/A | 154 (74.0%) | 48 (71.6%) | 23 (60.5%) | 6 (54.5%) | |||
| G/G + A/G | 54 (26.0%) | 19 (28.4%) | 0.70 | 15 (39.5%) | 0.09 | 5 (45.5%) | 0.14 | |
| Allele | A | 358 (86.1%) | 114 (85.1%) | 58 (76.3%) | 17 (77.3%) | |||
| G | 58 (13.9%) | 20 (14.9%) | 0.78 | 18 (23.7%) | 0.03 | 5 (22.7%) | 0.20 | |
| CYP2E1 | ||||||||
| Genotype | C1/C1 | 117 (56.2%) | 39 (58.2%) | 27 (71.1%) | 8 (72.7%) | |||
| C2/C2 + C1/C2 | 91 (43.8%) | 28 (41.8%) | 0.78 | 11 (28.9%) | 0.09 | 3 (27.3%) | 0.23 | |
| Allele | C1 | 307 (73.8%) | 102 (76.1%) | 62 (81.6%) | 19 (86.4%) | |||
| C2 | 109 (26.2%) | 32 (23.9%) | 0.59 | 14 (18.4%) | 0.15 | 3 (13.6%) | 0.19 | |
| ALDH2 | ||||||||
| Genotype | *1/*1 | 125 (60.1%) | 39 (58.2%) | 25 (65.8%) | 9 (81.8%) | |||
| *2/*2 + *1/*2 | 83 (39.9%) | 28 (41.8%) | 0.78 | 13 (34.2%) | 0.51 | 2 (18.2%) | 0.13 | |
| Allele | *1 | 326 (78.4%) | 105 (78.4%) | 60 (78.9%) | 20 (90.9%) | |||
| *2 | 90 (21.6%) | 29 (21.6%) | 1.00 | 16 (21.1%) | 0.91 | 2 (9.1%) | 0.12 | |
| SOD2 | ||||||||
| Genotype | Val/Val | 159 (76.4%) | 52 (77.6%) | 28 (73.7%) | 5 (45.5%) | |||
| Ala/Ala + Val/Ala | 49 (23.6%) | 15 (22.4%) | 0.84 | 10 (26.3%) | 0.71 | 6 (54.5%) | 0.03 | |
| Allele | Val | 365 (87.7%) | 116 (86.6%) | 65 (85.5%) | 15 (68.2%) | |||
| Ala | 51 (12.3%) | 18 (13.4%) | 0.72 | 11 (14.5%) | 0.59 | 7 (31.8%) | 0.02 | |
a. p value <0.05 is considered statistically significant
b. Pearson′s chi-square test
c. Fisher’s exact test