Table 3. Odds ratios of chemical sensitive population (CSP) cases compared to controls categorized by genotype.
| Variable a | Control |
Case 1 (Low chemical sensitivity)
|
Case 2 (Middle chemical sensitivity)
|
Case 3 (High chemical sensitivity)
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n=208 | n=67 |
n=38 |
n=11 |
||||||||||
| OR (95% CI) | Pc | ORb (95% CI) | Pc | OR (95% CI) | Pc | ORb (95% CI) | Pc | OR (95% CI) | Pc | ORb (95% CI) | Pc | ||
| Crude | Adjusted | Crude | Adjusted | Crude | Adjusted | ||||||||
| NAT2 | |||||||||||||
| Genotype Slow + Inter vs. Rapid | 1d | 0.66 (0.38–1.14) | 0.14 | 0.68 (0.38–1.19) | 0.17 | 0.69 (0.34–1.37) | 0.29 | 0.68 (0.34–1.36) | 0.27 | 0.44 (0.12–1.54) | 0.20 | 0.48 (0.13–1.70) | 0.25 |
| Slow vs. Inter vs. Rapid | 1d | 0.70 (0.43–1.12) | 0.13 | 0.70 (0.43–1.14) | 0.15 | 0.68 (0.37–1.24) | 0.21 | 0.66 (0.36–1.22) | 0.18 | 0.43 (0.13–1.38) | 0.16 | 0.47 (0.14–1.51) | 0.20 |
| GSTM1 | |||||||||||||
| Genotype homozygous-null vs. non-null | 1d | 1.13 (0.65–1.96) | 0.67 | 1.09 (0.62–1.93) | 0.76 | 1.55 (0.77–3.09) | 0.22 | 1.51 (0.75–3.04) | 0.25 | 2.43 (0.69–8.57) | 0.17 | 2.34 (0.66–8.30) | 0.19 |
| GSTT1 | |||||||||||||
| Genotype homozygous-null vs. non-null | 1d | 0.79 (0.45–1.37) | 0.40 | 0.75 (0.42–1.32) | 0.32 | 0.68 (0.34–1.36) | 0.27 | 0.66 (0.33–1.33) | 0.24 | 0.81 (0.24–2.75) | 0.81 | 0.84 (0.25–2.87) | 0.78 |
| GSTP1 | |||||||||||||
| Genotype G/G + A/G vs. A/A | 1d | 1.13 (0.61–2.09) | 0.70 | 1.06 (0.57–1.98) | 0.86 | 1.86 (0.91–3.82) | 0.09 | 1.76 (0.85–3.64) | 0.13 | 2.38 (0.70–8.10) | 0.17 | 2.48 (0.72–8.55) | 0.15 |
| G/G vs. A/G vs. A/A | 1d | 1.08 (0.62–1.89) | 0.78 | 1.02 (0.58–1.81) | 0.93 | 1.88 (1.04–3.41) | 0.04 | 1.79 (0.98–3.28) | 0.06 | 1.85 (0.64–5.31) | 0.26 | 1.95 (0.66–5.75) | 0.23 |
| CYP2E1 | |||||||||||||
| Genotype C2/C2 + C1/C2 vs. C1/C1 | 1d | 0.92 (0.53–1.61) | 0.78 | 0.96 (0.54–1.71) | 0.90 | 0.52 (0.25–1.11) | 0.09 | 0.50 (0.24–1.08) | 0.08 | 0.48 (0.12–1.87) | 0.29 | 0.52 (0.13–2.06) | 0.35 |
| C2/C2 vs. C1/C2 vs. C1/C1 | 1d | 0.89 (0.58–1.38) | 0.61 | 0.94 (0.59–1.47) | 0.78 | 0.67 (0.37–1.20) | 0.18 | 0.65 (0.35–1.18) | 0.16 | 0.47 (0.14–1.57) | 0.22 | 0.50 (0.15–1.67) | 0.26 |
| ALDH2 | |||||||||||||
| Genotype *2/*2 + *1/*2 vs. *1/*1 | 1d | 1.08 (0.62–1.89) | 0.78 | 1.02 (0.55–1.89) | 0.95 | 0.78 (0.38–1.62) | 0.51 | 0.61 (0.27–1.36) | 0.22 | 0.34 (0.07–1.59) | 0.17 | 0.26 (0.05–1.40) | 0.12 |
| *2/*2 vs. *1/*2 vs. *1/*1 | 1d | 1.00 (0.61–1.65) | 1.00 | 0.95 (0.54–1.67) | 0.85 | 0.97 (0.53–1.77) | 0.91 | 0.78 (0.40–1.53) | 0.47 | 0.34 (0.08–1.53) | 0.16 | 0.27 (0.05–1.35) | 0.11 |
| SOD2 | |||||||||||||
| Genotype Ala/Ala + Val/Ala vs. Val/Val | 1d | 0.94 (0.49–1.81) | 0.84 | 0.89 (0.46–1.75) | 0.74 | 1.16 (0.53–2.55) | 0.71 | 1.09 (0.49–2.42) | 0.84 | 3.90 (1.14–13.31) | 0.03 | 4.30 (1.23–15.03) | 0.02 |
| Ala/Ala vs. Val/Ala vs. Val/Val | 1d | 1.11 (0.63–1.96) | 0.72 | 1.03 (0.58–1.85) | 0.91 | 1.22 (0.60–2.50) | 0.59 | 1.11 (0.54–2.30) | 0.78 | 3.67 (1.32–10.20) | 0.01 | 4.53 (1.52–13.51) | 0.01 |
a. OR, odds ratio; 95% CI, 95% confidence interval
b. Odds Ratios were adjusted by age, smoking, and drinking
c. p value <0.05 is considered statistically significant
d. Reference category