Figure 9. Endoglin-Mediated Suppression of Invasion is Dependent on ActRIIA Kinase Domain and Independent of BMPRII Kinase Activity or Tail Domain.

Cells were transfected with endoglin, ActRIIA (A) or BMPRII constructs (B), and ActRIIA or BMPRII directed siRNA, as indicated, and cell invasion assays conducted as in Figure 1. Data represent the mean ± SEM of N = 2 independent experiments (A) or N = 3 independent experiments (B), each in replicates of 3. * denotes p≤0.05 compared to cells transfected with empty vector and non-targeting siRNA.