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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Helicobacter. 2013 Apr 21;18(5):363–372. doi: 10.1111/hel.12055

Figure 4.

Figure 4

Time course of urease activation in the ΔexbD in the presence of high nickel. H. pylori ΔexbD strain was incubated in BHI, pH 5.5 or 7.4, in the presence of 250 μM NiCl2 for 30 to 180 min, and total urease activity was measured in the presence of the nonionic detergent C12E8 to bypass UreI. In the presence of supraphysiologic levels of nickel, the acid-induced activation of urease activity over time is restored in the ΔexbD.