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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Mol Cancer Ther. 2013 May 30;12(8):1504–1514. doi: 10.1158/1535-7163.MCT-12-1197

Figure 3.

Figure 3

Other microtubule disrupting drugs induce Noxa and sensitize CLL cells to ABT-737. Freshly-isolated lymphocytes from CLL patients were incubated with vinblastine, vincristine, vinorelbine or combretastatin A4 alone (A) or in combination with ABT-737 (B) for 6 h. (A) Cell lysates were analyzed for protein expression, using THP-1 cells as a positive control for protein expression. Representative western blots for each drug are shown (vinca alkaloids n=13, combretastatin A4 n=6). (B) Apoptosis was assessed by chromatin condensation and the percentage of surviving cells is shown. Representative data from one of two patients is shown.