Table 2. meta analysis of the two SNPs detected in the first-set screening analysis.
P value of original study | current study (screeing+replication) | current study+PGC BP | current study+Lee et al. | current study+Lee et al.+PGC BP | |||||||||||||||
Chr | SNP | GENE | A1a | A2b | PGC BP | Lee et al.c | phenotyped | P | ORe | I2 | P | ORe | I2 | P | ORe | I2 | P | ORe | I2 |
3 | rs2251219 | PBRM1 | A | G | 5.5E-07 | - | BD | 0.0048 | 1.13 | 0 | 9.4E-09 | 1.13 | 0 | ||||||
SCZ | 0.00016 | 1.15 | 0 | 4.3E-10 | 1.13 | 0 | |||||||||||||
Psychosis | 8.0E-05 | 1.14 | 0 | 2.0E-10 | 1.13 | 0 | |||||||||||||
7 | rs2709722 | SP8 | T | C | 0.089 | 5.06E-05 | BD | 0.0016 | 0.86 | 0 | 0.0322 | 0.91 | 56.2 | 5.1E-07 | 0.84 | 0 | 0.0070 | 0.88 | 72.9 |
SCZ | 0.0030 | 0.89 | 46.6 | 0.0332 | 0.92 | 58.4 | 1.6E-06 | 0.86 | 42.2 | 0.0074 | 0.89 | 73.9 | |||||||
Psychosis | 0.00040 | 0.88 | 32.4 | 0.0212 | 0.91 | 64.6 | 2.1E-07 | 0.86 | 30.3 | 0.0043 | 0.89 | 74.7 |
a: A1: first allele code.
b: A2: second allele code.
c: Lee et al. reported the P values based upon dominant model. To conduct meta-analysis of allelic model, we re-caluculated P values based upon their results.
d: BD: bipolar disorder, SCZ: schizophrenia.
e: the effect is with respect to the A1 allele.