Figure 4. Proliferation assay of non-transformed human breast epithelial cells and breast carcinoma cell lines that overexpress Dmp1:ER.

(a) HMEC (human mammary epithelial cells); HER2^low, ARF⁺, p53⁺

(b) MCF10A; HER2^low, ARF⁻, p53⁺

(c) MCF7; HER2^low, ARF⁻, p53⁺

(d) HCC1569; HER2⁺⁺, ARF⁺, p53^del

(e) ZR-75-1; HER2^high, ARF⁺, p53⁺

(f) BT-549; HER2^low, ARF⁺, p53^mut

solid lines show the growth curves of Dmp1:ER virus-infected cells treated with 2 μM 4-HT, discontinuous lines show those of mock-infected cells with 4-HT.