Table 2. Subclassification of breast cancers studied and relationship with hDMP1 and p53 LOH.
All the breast cancer cases (n=104, enough information was not available in 6 cases) have been subclassified into luminal A, luminal B, HER2, triple-negative/basal type, and unclassified/normal-type based on the data from histochemical studies for ER, PR, HER2, Ki67, cytokeratin, and morphology of tumor cells as described in the Materials and Methods. The percentage of our breast cancer samples in each category was very close to those reported in the literature. hDMP1 LOH(+) breast cancers were significantly associated with luminal A category while p53 LOH(+) breast cancers were associated with non-luminal A subtype.
| hDMP1 LOH(+) | hDMP1 LOH(−) | Pecentage | p values | |
|---|---|---|---|---|
| Luminal A | 19 | 13 | 45.2 | 0.0085 |
| Luminal B | 8 | 15 | 19.0 | 0.5350 |
| HER2 | 5 | 17 | 21.1 | 0.0573 |
| Triple-negative | 6 | 12 | 11.9 | 0.5026 |
| Normal/unclassified | 4 | 5 | 9.5 | 0.7951 |
| Not evaluated | 4 | 2 | ||
| total | 46 | 64 | ||
| p53 LOH(+) | p53 LOH(−) | Pecentage | p values | |
| Luminal A | 6 | 26 | 16.7 | 0.0234 |
| Luminal B | 8 | 15 | 22.2 | 0.9848 |
| HER2 | 10 | 12 | 27.8 | 0.2288 |
| Triple-negative | 8 | 10 | 22.2 | 0.3342 |
| Normal/unclassified | 4 | 5 | 11.1 | 0.5546 |
| Not evaluated | 2 | 4 | ||
| total | 38 | 72 | ||
| All cases | Pecentage | Reported percentage | ||
| Luminal A | 32 | 29.1 | 28 | |
| Luminal B | 23 | 20.9 | 19 | |
| HER2 | 22 | 20.0 | 17 | |
| Triple-negative | 18 | 16.4 | 27 | |
| Normal/unclassified | 9 | 8.2 | 8 | |
| unknown | 6 | 5.4 | ||
| total | 110 |