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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Magn Reson Med. 2013 May 9;71(4):1592–1602. doi: 10.1002/mrm.24782

Table 4.

ROC analysis of percent change in SER washout and kep for predicting treatment response. The 95% confidence intervals (CI) were also calculated for sensitivity, specificity, and AUC.

Parameter Optimal
Cutoff
(%)		 Sensitivity (%)
(95% CI)		 Specificity (%)
(95% CI)		 AUC1
(95% CI)
%SER_washout −60 91
(62 - 99)		 65
(41 - 83)		 0.752
(0.55 - 0.91)
%kep, TK −5 100
(74 - 100)		 59
(36 - 78)		 0.782
(0.60 - 0.94)
%kep, ETK −19 91
(62 - 99)		 65
(41 - 83)		 0.762
(0.57 - 0.92)
%kep, FXR −20 82
(52 - 95)		 59
(36 - 78)		 0.73
(0.55 - 0.91)
1

Lower limits for AUC that exclude 0.5 indicate the accuracy of the parameter exceeds what would be expected by chance alone.

2

These parameters retain statistical significance following a Bonferroni correction that protects the overall type I error inference for AUC at 5%.