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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Exp Neurol. 2013 May 18;247:250–258. doi: 10.1016/j.expneurol.2013.05.006

Figure 2.

Figure 2

Dose dependent effect of methysergide on pudendal nerve stimulation (PNS)-induced inhibition of bladder overactivity caused by acetic acid (AA) irritation. The CMGs were performed in sequence from left to right in figures A–C and from top to bottom in each figure. PNS duration is indicated by black bar under bladder pressure trace. T – PNS threshold intensiy for inducing anal sphincter twitching. A. Control CMGs without PNS. B. CMGs during 1–2T PNS. C. CMGs during 3–4T PNS. PNS: 5 Hz, 0.2 ms, T = 0.5 V. Infusion rate = 1 ml/min.