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Effect of naloxone on bladder activity and pudendal nerve stimulation (PNS)-induced inhibition after methysergide treatment. PNS duration is indicated by black bar under bladder pressure trace. T – PNS threshold intensity for inducing anal sphincter twitching. A. CMGs during acetic acid (AA) infusion. PNS: 5 Hz, 0.2 ms, T = 1.6 V. Infusion rate = 1 ml/min. B. CMGs during saline infusion. PNS: 5 Hz, 0.2 ms, T = 0.6 V. Infusion rate = 2 ml/min.
