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. Author manuscript; available in PMC: 2014 Sep 10.
Published in final edited form as: Exp Cell Res. 2013 Mar 31;319(15):2316–2322. doi: 10.1016/j.yexcr.2013.03.024

Fig. 1. A working model for the role of ciliary Arls.

Fig. 1

Arl3 stabilize the association between IFT-B and the KIF17 motor in an HDAC-6-dependent manner; GTP-bound ARL3 binds to UNC119/myristoylated-NPHP3 complex and release NPHP3 into the cilium. GTP-bound ARL3 works together with different effectors to mediate the proper ciliary trafficking/targeting of transducin. GTP-bound Arl6 recruits the BBSome and sensory receptors into cilia. ARL-13 enhances the association between IFT-A and IFT-B subcomplexes; The SUMOylation of Arl13b by UBC9 is required for the ciliary targeting of sensory receptors; GTP-bound Arl13b interacts with and facilitates the ciliary targeting of INPP5E. Dashed lines indicate the underlying molecular mechanisms remain unclear.