FIG. 1.

Antiviral activity of human MxA protein against CCHFV. Vero cells constitutively expressing wild-type MxA (VA9, VA12, and VA3), nontransfected Vero cells, cells expressing only the neomycin resistance gene (VN36 and VN41) and cells expressing a mutant form of MxA [VA(E645R)] were infected with CCHFV at an MOI of 0.01. At 24 and 48 hpi, the cells and supernatants were harvested and the amount of infectious virus was determined as described in Materials and Methods. The mean log titers given are the average of three independent experiments. Error bars indicate standard deviations.