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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Mol Cancer Ther. 2013 May 16;12(8):1545–1555. doi: 10.1158/1535-7163.MCT-12-0933

Fig. 3.

Fig. 3

Vorinostat treatment effects in human lung cancer cell lines. (A) Vorinostat inhibited growth in a concentration- and time-dependent manner in HOP62 (left panel), H522 (middle panel) and H23 (right panel) human lung cancer cells versus vehicle controls. (B) Vorinostat induced apoptosis in a representative lung cancer cell line (HOP62). (C) Growth inhibition was antagonized by vorinostat washout of HOP62 cells. (D) Vorinostat induced similar dose-dependent changes in protein expression in human HOP62 versus murine lung cancer cell lines (Figs. 1 and 2). Signal intensity is shown in the right panel. Symbols * and ** revealed significant changes, P < 0.05 and P < 0.01, respectively.