Table 1. Distribution of Val66Met genotype and allele in schizophrenic patients with or without MetS.
| Genotype distribution (%) | Odds ratio (95% CI) | p c | Allele (%) | p c | ||||||
| MetS group | n | Val/Val | Val/Met | Met/Met | n | Val | Met | |||
| Total (Males, Females) | 86 | 20 (23.3) | 45 (52.3) | 21 (24.4) | 1.71 (0.84–3.45) a | 0.15 | 172 | 85 (49.4) | 87 (50.6) | 0.52 |
| 0.89 (0.45–1.75) b | 0.73 | |||||||||
| Males | 57 | 11 (19.3) | 29 (50.9) | 17 (29.8) | 2.39 (1.05–5.41) a | 0.039 | 114 | 51 (44.7) | 63 (55.3) | 0.10 |
| 1.35 (0.59–3.07) b | 0.54 | |||||||||
| Females | 29 | 9 (31.0) | 16 (55.2) | 4 (13.8) | 0.70 (0.17–2.95) a | 0.73 | 58 | 34 (58.6) | 24 (41.4) | 0.19 |
| 0.27 (0.07–1.17) b | 0.10 | |||||||||
| non-MetS group | ||||||||||
| Total (Males, Females) | 113 | 24 (21.2) | 71 (62.8) | 18 (15.9) | 226 | 119 (52.7) | 107 (47.3) | |||
| Males | 86 | 21 (24.4) | 52 (60.5) | 13 (15.1) | 172 | 94 (54.7) | 78 (45.3) | |||
| Females | 27 | 3 (11.1) | 19 (70.4) | 5 (18.5) | 54 | 25 (46.3) | 29 (53.7) | |||
The Odds ratio was calculated for MetS group homozygous for Met allele a (Met/Met vs. Val/Val+Val/Met), and homozygous or heterozygous for Met allele b (Met/Met+Val/Met vs Val/Val).
c
p values were not corrected for multiple test.