Table 3. BDNF Val66Met polymorphism and individual parameters in males and females.
| Males, mean (S.D.) | Females, mean (S.D.) | |||||||
| Val/Val (n = 32) | Val/Met (n = 81) | Met/Met (n = 30) | p a | Val/Val (n = 12) | Val/Met (n = 35) | Met/Met (n = 9) | p a | |
| Waist circumference | 89.1 (6.0) | 89.1 (4.9) | 88.7 (5.4) | 0.87 | 85.0 (4.6) | 81.9 (6.7) | 81.2 (7.3) | 0.13 |
| Fasting GLU (mmol/l) | 5.6 (1.5) | 5.6 (1.1) | 6.5 (1.5) | 0.005 | 5.9 (1.2) | 5.6 (1.2) | 5.2 (0.8) | 0.65 |
| Fasting TG (mmol/l) | 1.6 (0.9) | 1.5 (0.9) | 1.3 (0.6) | 0.52 | 1.6 (0.5) | 1.8 (1.1) | 1.1 (0.3) | 0.09 |
| Fasting HDL (mmol/l) | 1.1 (0.4) | 1.2 (0.4) | 1.0 (0.4) | 0.10 | 1.0 (0.6) | 1.2 (0.5) | 1.3 (0.3) | 0.07 |
| SBP (mm Hg) | 119.5 (10.1) | 118.3 (10.2) | 119.8 (10.1) | 0.82 | 119.2 (6.0) | 119.4 (9.8) | 120.6 (8.8) | 0.92 |
| DBP (mm Hg) | 77.8 (5.4) | 76.8 (5.9) | 76.5 (6.7) | 0.15 | 77.9 (5.4) | 76.9 (5.4) | 77.8 (5.1) | 0.56 |
a
p values were adjusted for age, duration of clozapine treatment, and drug dose, and not corrected for multiple test.