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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Exp Neurol. 2013 Apr 6;247:73–79. doi: 10.1016/j.expneurol.2013.04.001

Figure 1.

Figure 1

Schematic representation of strategy to improve survival of transplanted NPCs. A TetON system, consisting of M2rtTA driven by the human ubiquitin C (hUbC) promotor and the target genes (bFGF and mCherry) driven by a TRE promoter, are cloned into a lentivector for transduction of 293 and C17.2 helper cells. NPCs and helper cells are co-engrafted and at certain time points after transplantation, Dox is administered to induce target gene expression in helper cells. bFGF is then being produced, triggering activation of signaling pathways that enhance NPC survival.