Table II.
p38β promoter region polymorphism (rs2235356, -1628A>G) is correlated with an increased risk of CRC.
| No. cases (%) | No. controlsa (%) | P-valueb | Crude OR (95% CI) | Adjusted ORc (95% CI) | |
|---|---|---|---|---|---|
| Total no. subjects | 855 | 871 | |||
| Total no. alleles | 1710 | 1742 | |||
| Rs2235356A>G genotype | <.0001 | ||||
| AA | 214 (25.0) | 343 (39.4) | 1.00 (ref.) | 1.00 (ref.) | |
| AG | 551 (64.5) | 410 (47.1) | 2.15 (1.74–2.76) | 2.22 (1.78–2.79) | |
| GG | 90 (10.5) | 118 (13.5) | 1.22 (0.89–1.69) | 1.21 (0.86–1.70) | |
| AG+GG | 641 (75.0) | 528 (60.6) | 1.95 (1.58–2.39) | 1.99 (1.60–2.47) | |
| Trend test P-value | 0.0002 | 0.0004 | |||
| G allele | 0.427 | 0.371 | <.0001 |
a
Observed genotype frequencies among the control subjects were in agreement with Hardy-Weinberg equilibrium [p2+2pq+q2=1, where p represents the frequency of allele (A) and q represents the frequency of allele (G)] (χ2=0.067 and P= 0.796 for rs2235356A>G);
b
two-sided χ2 test to demonstrate the differences in the distribution of genotype frequencies between cases and controls;
c
adjusted in a logistic regression model that included age, gender, smoking status, alcohol use, body mass index and family history of cancer. OR, odds ratio; CI, confidence interval; CRC, colorectal cancer.