Table III.
Stratification analysis of the p38β promoter region polymorphism (rs2235356, -1628A>G) genotypes by selected variables in patients with CRC and cancer-free control subjects.
| Variable | No. cases (n=855) (%)
|
No. controls (n=871) (%)
|
Crude OR (95% CI) AG+GG vs. AA | Adjusted ORa (95% CI) AG+GG vs. AA | P-valueb | ||
|---|---|---|---|---|---|---|---|
| AA | AG+GG | AA | AG+GG | ||||
| Age (years) | 0.2772 | ||||||
| ≤60 | 103 (23.8) | 329 (76.2) | 182 (39.9) | 274 (60.1) | 2.12 (1.59–2.84) | 2.11 (1.56–2.87) | |
| > 60 | 111 (26.2) | 312 (73.8) | 161 (38.8) | 254 (61.2) | 1.78 (1.33–2.39) | 1.97 (1.43–2.72) | |
| Gender | 0.2622 | ||||||
| Male | 135 (25.9) | 386 (74.1) | 204 (38.6) | 325 (61.4) | 1.80 (1.38–2.33) | 1.82 (1.36–2.44) | |
| Female | 79 (23.7) | 255 (76.3) | 139 (40.6) | 203 (59.4) | 2.21 (1.59–3.08) | 2.10 (1.50–2.94) | |
| Smoking status | 0.0770 | ||||||
| Smoker | 112 (27.1) | 302 (72.9) | 154 (37.9) | 252 (62.1) | 1.65 (1.23–2.21) | 1.68 (1.20–2.35) | |
| Non-smoker | 102 (23.1) | 339 (76.9) | 189 (40.6) | 276 (59.4) | 2.28 (1.71–3.04) | 2.22 (1.66–2.97) | |
| Drinking status | 0.0501 | ||||||
| Not teetotal | 114 (28.5) | 286 (71.5) | 76 (37.3) | 128 (62.7) | 1.49 (1.04–2.13) | 1.47 (1.02–2.12) | |
| Teetotal | 100 (22.0) | 355 (78.0) | 267 (40.0) | 400 (60.0) | 2.37 (1.81–3.11) | 2.37 (1.79–3.14) | |
| BMI (kg/m2) | 0.3030 | ||||||
| <18 | 9 (16.1) | 47 (83.9) | 12 (34.3) | 23 (65.7) | 2.72 (1.01–7.39) | 3.63 (1.01–13.0) | |
| 18–25 | 129 (23.2) | 428 (76.8) | 231 (38.0) | 377 (62.0) | 2.03 (1.57–2.63) | 2.01 (1.53–2.62) | |
| >25 | 76 (31.4) | 166 (68.6) | 100 (43.9) | 128 (56.1) | 1.71 (1.17–2.49) | 1.94 (1.29–2.92) | |
| Family history of cancer | 0.0578 | ||||||
| Yes | 23 (24.0) | 73 (76.0) | 19 (26.4) | 53 (73.6) | 1.14 (0.56–2.30) | 1.04 (0.49–2.21) | |
| No | 191 (25.2) | 568 (74.8) | 324 (40.5) | 475 (59.5) | 2.03 (1.63–2.52) | 2.12 (1.69–2.66) | |
a
Adjusted for age, gender, smoking status, alcohol use, body mass index (BMI) and family history of cancer in a logistic regression model;
b
calculated using a standard unconditional logistic regression model for the multiplicative interactions between the rs2235356 1628A>G polymorphism and selected variables. OR, odds ratio; CI, confidence interval; CRC, colorectal cancer.