Figure 1.

Antiproliferative effects of the vehicle, dacarbazine (DTIC), axitinib, and axitinib and DTIC combination treatments in mice inoculated with melanoma xenografts. (A) The tumor volume was monitored and recorded. ^**P<0.01 and ^***P<0.001, compared with the control group. (B) Representative photographs of the tumor sections are shown. (C) Tumors excised at day 14 were weighed. (D) Liver and (E) spleen indices. The experiments were performed three times with identical results. Data are expressed as the mean ± SEM. The number of mice in each group is 10. ^*P<0.05, ^**P<0.01 and ^***P<0.001. NS, not significant.