Figure 2.

Following the administration of axitinib, dacarbazine (DTIC), a combination of axitinib and dacarbazine, or vehicle, tumor tissue sections were obtained from mice that had previously been inoculated with melanoma xenografts. The sections were stained with hematoxylin and eosin (H&E), antibody specific to proliferating cell nuclear antibody (PCNA) and terminal deoxynucleotidyl-transferase-mediated dUTP nick end labeling (TUNEL), to detect changes in the levels of necrosis, proliferation and apoptosis, respectively. Original magnification, ×200.