Table II.
Correlations between HER2 gene amplification and clinicopathological parameters.
| Characteristic | ESCC
|
GEJAC
|
GC
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | HER2+ | χ2 | P value | n | HER2+ | χ2 | P value | n | HER2+ | χ2 | P value | |
| Gender | ||||||||||||
| Male | 57 | 3 | 38 | 8 | 41 | 6 | ||||||
| Female | 19 | 0 | 1.041 | 0.308 | 12 | 4 | 0.754 | 0.385 | 17 | 3 | 0.083 | 0.773 |
| Age | ||||||||||||
| <65 | 46 | 2 | 24 | 4 | 33 | 7 | ||||||
| ≥65 | 30 | 1 | 0.049 | 0.824 | 26 | 8 | 1.361 | 0.243 | 25 | 2 | 1.894 | 0.169 |
| Differentiation | ||||||||||||
| Well, moderately | 56 | 2 | 24 | 7 | 18 | 4 | ||||||
| Poorly | 20 | 1 | 0.079 | 0.778 | 26 | 5 | 0.675 | 0.411 | 40 | 5 | 0.895 | 0.344 |
| Depth of invasion | ||||||||||||
| T1+T2 | 46 | 0 | 18 | 6 | 22 | 4 | ||||||
| T3+T4 | 30 | 3 | 4.789 | 0.029 | 32 | 6 | 1.343 | 0.246 | 36 | 5 | 0.192 | 0.661 |
| Vascular invasion | ||||||||||||
| Yes | 34 | 3 | 40 | 8 | 43 | 5 | ||||||
| No | 42 | 0 | 3.858 | 0.050 | 10 | 4 | 1.754 | 0.185 | 15 | 4 | 1.919 | 0.166 |
| Lymph node metastasis | ||||||||||||
| Yes | 28 | 3 | 28 | 7 | 31 | 4 | ||||||
| No | 48 | 0 | 5.354 | 0.021 | 22 | 5 | 0.035 | 0.852 | 27 | 5 | 0.347 | 0.556 |
HER2, human epidermal growth factor receptor 2; ESCC, esophageal squamous cell carcinoma; GEJAC, gastroesophageal junction adenocarcinoma; GC, gastric cancer.