Table II.
Correlation between the expression of VEGF and its receptors, and hepatic metastasis and ascites in ovarian cancer.
| Category | Cases, n | VEGF
|
Flt-1
|
KDR
|
VEGF/Flt-1
|
VEGF/KDR
|
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| n (%) | P-value | n (%) | P-value | n (%) | P-value | n (%) | P-value | n (%) | P-value | ||
| Lymph node | |||||||||||
| (+) | 28 | 24 (85.7) | 20 (71.4) | 15 (53.4) | 20 (71.4) | 13 (46.4) | |||||
| (−) | 20 | 8 (40.0) | 0.009 | 8 (40.0) | 0.02 | 6 (30.0) | 0.1 | 6 (30.0) | 0.005 | 6 (30.0) | 0.25 |
| Hepatic metastasis | |||||||||||
| With | 8 | 7 (87.5) | 6 (75.0) | 7 (87.5) | 6 (75.0) | 7 (87.5) | |||||
| Without | 40 | 25 (62.5) | 0.36 | 22 (55.0) | 0.5 | 14 (35.0) | 0.02 | 20 (50.0) | 0.39 | 12 (30.0) | 0.005 |
| Ascites (ml) | |||||||||||
| ≥1000 | 30 | 24 (75.0) | 21 (70.0) | 16 (53.3) | 21 | 13 | |||||
| <1000 | 18 | 8 (44.4) | 0.01 | 7 (38.9) | 0.04 | 5 (27.8) | 0.09 | 5 | 0.005 | 6 | 0.49 |
VEGF, vascular endothelial growth factor.