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. 2013 Jun 3;4(5):751–760. doi: 10.18632/oncotarget.1044

Figure 4. Human pancreatic cancer lines grown in nude mice were analyzed with the Human Cancer Pathway Finder RT Profiler PCR Array.

Figure 4

The bars show fold changes compared to control. *= P<0.05 vs control. The genes are grouped according to their functions as follows. (A) Invasion and metastasis: TWIST1: Twist homolog 1; TIMP3: TIMP metallopeptidase inhibitor 1; SERPINE1: Serpine peptidase inhibitor, clade E, member 1; SERPINB5: Serpin peptidase inhibitor, clade B, member 5; PLAUR: Plasminogen activator, urokinase receptor; NME4, NME1: Non-metastatic cells protein 4, 1; MMP9, 2, 1: Matrix metallopeptidase 9, 2, 1. Angiogenesis: THBS1: Thrombospondin 1; TGFBR1: Transforming growth factor beta receptor 1; TEK: TEK tyrosine kinase; IL8: Interleukin 8; IGF1: Insulin-like growth factor 1; IFNB1: Interferon, beta 1; IFNA1: Interferon, alpha 1; FGFR2: Fibroblast growth factor receptor 2; COL18A1: Collagen, type XVIII, alpha 1; AGPT2, 1: Angiopoietin 2, 1. Adhesion: EPDR1: Ependymin related protein 1; SYK: Spleen tyrosine kinase; MCAM: Melanoma cell adhesion molecule; ITGB, ITGA: Integrin beta, alpha. (B) Signal transduction molecules and transcription factors: SNCG: Synuclein gamma (breast cancer specific protein); PIK3R1: Phosphoinositide-3-kinase, regulatory subunit 1; MAP2K1: Mitogen-activated protein kinase 1; ETS2: V-Ets erythroblastosis virus E26 oncogene homolog 2; AKT1: V-akt murine thymoma viral oncogene homolog 1. Apoptosis and cell senescence: TNFRSF25, 1A, 10B: Tumor necrosis factor receptor superfamily member 25, 1a, 10b; TERT: Telomerase reverse transcriptase; GZMA: Granzyme A; FAS: Fas (TNF receptor superfamily, member 6; CFLAR: CASP8 and FADD-like apoptosis regulator; CASP8: Caspase 8; BCL2L1: BCL2-like 1; BCL2: B-cell CLL/lymphoma 2. Cell cycle control and DNA damage repair: TP53: Tumor protein p53; RB1: Retinoblastoma 1; E2F1: E2F transcription factor 1; CDKN2A, 1A: Cyclin-dependent kinase inhibitor 2A, 1A; CDC25A: Cell division cycle 25 homolog A; BRCA1: Breast cancer 1; ATM: Ataxia telangiectasia mutated.