Table 1. Effect of treatment with cytotoxic LH-RH analog AN-152 on volume and weights of human pancreatic cancers in nude mice.
| Experiments/Groups | Tumor volume (final) (mm3) | Tumor weights (mg) | |
|---|---|---|---|
| Panc-1 | |||
| Control | 2040±1357 | 606±340d | |
| AN-152 | 183±76a | 93±161a | |
| DOX | 849±363 | 689±139 | |
| 2. SW-1990 | Tumors with cysts Solid tumor part Cystic/solid tumor | ||
| Control | 3464±838 | 3729±921 2473±636 1.56±0.12 | |
| AN-152 | 919±248a | 1160±288a 371±69a 2.58±0.42b | |
| DOX | 1213±381a | 1496±466 585±141a 1.93±0.30 | |
| 4. D-Trp6[LH-RH] | 2791±646 | 3107±696 1862±361 1.56±0.11 | |
| 3.CFPAC-1 | |||
| Control | 2502±769 | 518±244c | |
| AN-152 | 338±81a | 360±102 | |
| DOX | 1063±518 | 540±140 | |
Values are means ± SE aP<0.05 vs. Control bP<0.05 vs. all other groups cSome tumors in these experiments contained cysts and were weighed after cysts were cut and fluid released.