Fig. 9.

Distribution of CFTR and AQP5 in healthy control and celiac disease- and CF (ΔF508 CFTR)-affected human proximal duodenum. Immunohistochemical staining for CFTR and aquaporin 5 (AQP5) in healthy controls, celiac disease, and CF (ΔF508 CFTR) proximal human duodenum tissue sections was performed as described in materials and methods. Low-magnification (A–F, left) and high-magnification (A–F, right) images show the distribution of CFTR (A–C) and AQP 5 (D–F) in healthy (A and D), celiac disease (B and E), and CF (ΔF508 CFTR) (C and F) proximal human duodenum and Brunner's gland. Apical membrane staining (brown) in Brunner's gland, is indicated by black arrows. Scale bar =10 or 100 μm.