Fig. 1.

Effects of cyclosporine A (CsA) and lovastatin on transepithelial resistance. Measurements of transepithelial resistance across mpkCCDc14 cell monolayers showed that CsA increased, but lovastatin decreased, transepithelial resistance. The effect of CsA was abolished by lovastatin. In each group, n = 12. All experiments shown in Figs. 1–4 were performed when cells were either under control conditions or treated for 24 h with 1 μM CsA, 25 μM lovastatin, or 1 μM CsA plus 25 μM lovastatin, respectively.