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Treatment with ER stress inhibitors TUDCA or PBA can attenuate increased acetylcholine (ACh) and arachidonic acid (AA)-induced contraction in the aorta of the SHR. Aortic rings were incubated with NG-nitro-l-arginine (l-NNA; 30 min, 100 μM) before ACh (10 nM to 100 μM; A) or AA (100 nM to 10 μM; B) concentration-response curves were performed. Data are means ± SE (n = 6–8). *P < 0.05 vs. control WKY rats. †P < 0.05 vs. control SHR.
