Fig. 3.

Treatment with ER stress inhibitors TUDCA or PBA can normalize endothelium-derived prostanoid release in the aorta of the SHR. Thromboxane B₂ (TXB₂; A), 6-keto-prostaglandin F_1α (6-keto-PGF1_α; B), and PGF_2α (C) release was measured in aortic rings incubated in physiological salt solution (37°C, 500 μl) with or without l-NNA (30 min, 100 μM) and stimulated with ACh (15 min, 10 μM) in the presence or absence of indomethacin (10 μM). Data are means ± SE (n = 5–7). *P < 0.05 vs. control WKY rats.