Fig. 7.

Treatment with ER stress inhibitors TUDCA or PBA can attenuate the increased tert-butyl hydroperoxide (t-BOOH)-induced contraction and H₂O₂ production in the aorta of the SHR. A: aortic rings were incubated with l-NNA (30 min, 100 μM) and a concentration-response curve to t-BOOH (1 μM to 1 mM) was performed. B: H₂O₂ production was measured using Amplex red and normalized to protein concentration. Data are means ± SE (n = 5–8). Symbols represent the results from 2-way ANOVA. *P < 0.05 vs. control WKY rats. † P < 0.05 vs. control SHR.