TABLE 2.

Evolution of resistance genotypes for patient B^a

Sequence no.	Parameter	Result at various times after protease inhibitor failure
		0 mo	19 mo	27 mo	33 mo	39 mo	43 mo
	Genotype (% total population)b
	Baseline 63P-77I	100
1	46I 82T		100
2	24I 46I 54V 71V 82T			99d	64
3	46I 82T 90M 93L			1
4	46I 54V 71V 82T 90M 93L				36	45	100e
5	24I 46I 54V 71V 82T 93L					55e
	Total no. of clones sequenced (with L90M/without L90M)			1/5	4/6	3/12	9/0
	% Total clones with L90M			1	36	45	100
	Treatmentc		AZT, 3TC, NFV	AZT, 3TC, NFV	AZT, 3TC, NFV	AZT, 3TC, NFV	AZT, 3TC, NFV

^aSee Table 1, footnote a.

^bSee Table 1, footnote b.

^cSee Table 1, footnote c.

^dSee Table 1, footnote d.

^eOrigin from a previously minority genotype (see Fig. 2).