Figure 2.

Dendritic filtering as a function of input amplitude. A, Schematic of the recording setup and example traces. A single CA1 pyramidal neuron was patched simultaneously at somatic and dendritic (mid-distal) locations. Voltage is monitored at both locations in current clamp while mEPSC-shaped currents of varying amplitudes are injected at the distal site. Black, top trace shows a representative recording from a somatic location while the lower, red trace shows a simultaneous recording from a dendritic location. Bottom, gray trace shows the injected current. B, Change in voltage as a function of the injected current amplitude recorded simultaneously at dendritic (in red) and somatic (in black) sites for a representative experiment. C, Average (mean ± SEM, n = 5) amplitude filtering, somatic voltage change as a percentage of the local dendritic voltage change, in response to a range of injected current amplitudes. Uniform filtering is evident without regard to input amplitude.