Figure 1.

Group 1 mGluR activation produces an sADP in CPn and COM neurons. A, CPn and COM neurons were driven to fire single or bursts of action potentials from a common membrane potential (−60 mV) before and after a 10 min application of 20 μm DHPG. B, In both CPn (n = 12) and COM (n = 10) neurons, the amplitude of the sADP increased after DHPG application (CPn, p < 0.001, RM-ANOVA; COM, p < 0.001, RM-ANOVA). For both cell types, the burst protocols produced a larger sADP than a single action potential. *p < 0.001 (post hoc comparisons). The effect of DHPG on the sADP was not statistically different in CPn versus COM neurons (p = 0.1, mixed ANOVA). The sADP during baseline conditions was measured at the same time point as the peak of the sADP during DHPG application. C, The area of the AHP was larger in COM neurons compared with CPn neurons during baseline conditions (p < 0.001, mixed ANOVA). *p < 0.01 (post hoc comparisons).