Figure 10.

Local dendritic mGluR-mediated sADPs in L5 neurons. A, Whole-cell recordings were obtained from the soma of CPn and COM neurons. DHPG was puffed either in L5 near the soma or at the border of L1/L2, near the start of the tuft. Modulation of the sADP was probed 3.5 s later by evoking a burst of 5 action potentials. B, mGluR activation near the soma modulated the size of the sADP in both neuron types. Puffing in L1 did not produce any detectable change in the sADP at the soma in either cell type (CPn, p < 0.001; COM, p = 0.001; RM-ANOVA). *p < 0.008 (post hoc comparisons). C, Same experimental design as A, except that recordings were obtained from the dendrite. D, mGluR activation near the soma or in L1 modulated the sADP as observed at the dendrite in both neuron types (CPn, p < 0.001; COM, p < 0.001; RM-ANOVA). *p < 0.025 (post hoc comparisons).