Figure 8.

mGluR-mediated sADP in the dendrites of L5 neurons. Whole-cell recordings were obtained from CPn-type (n = 18) and COM-type (n = 11) neurons at various distances from the soma. A burst of 5 spikes was evoked by brief depolarizing current pulses at the dendritic recording location before and after a 10 min DHPG (20 μm) application. A DHPG-mediated sADP was observed at every recording location in both cell types. Sample sADPs for each cell type are shown below. The average somatic sADP amplitude for 12 CPn neurons and 10 COM neurons is also plotted for reference (same data as Fig. 1).