Table 1.
Monte Carlo simulation study: agreement between the conventional and the optimization methods to fit the prespecified indexes of diastolic function
| Conventional Method |
Optimization Method |
|||||
|---|---|---|---|---|---|---|
| Ric | Bias | Random error | Ric | Bias | Random error | |
| τ, ms | 0.92 | 2 | 5 | 0.99 | 0 | 2 |
| V0, ml | 0.98 | 0 | 4 | 1.00 | 0.04 | 0.5 |
| S−, mmHg | 0.99 | 0.06 | 1.6 | |||
| Vd, ml | 0.84 | 0.09 | 3.6 | |||
| S+, mmHg | 0.92 | 0.21 | 5 | 0.99 | 0.15 | 1.41 |
| Vm, ml | 0.93 | 0.56 | 11 | 0.99 | 0.26 | 3.4 |
| dP/dV at V0, mmHg/ml | 0.94 | 10−4 | 0.1 | 0.99 | 10−4 | 0.02 |
| dP/dV at EDV, mmHg/ml | 0.97 | 0.04 | 0.1 | 0.99 | 10−4 | 0.05 |
Ric, intraclass correlation coefficient; τ, time constant of left ventricular (LV) relaxation; V0, equilibrium volume; S−, constant of diastolic elastic recoil; Vd, dead volume asymptote; S+, constant of diastolic passive stiffness; Vm, maximum volume asymptote; dP/dV, derivative of LV pressure with respect to volume; EDV: end-diastole volume.